Protein name:
Neutrophil elastase ;
Alternative:
Elastase-2 ;Bone marrow serine protease ;Medullasin ;Human leukocyte elastase (HLE) ;PMN elastase ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NOTCH2NL.
Function:
Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis.
Subcellular Location:
N/A
Protein Attributes:
50:
MTLGRRLACL | FLACVLPALL | LGGTALASEI | VGGRRARPHA | WPFMVSLQLR |
100:
GGHFCGATLI | APNFVMSAAH | CVANVNVRAV | RVVLGAHNLS | RREPTRQVFA |
150:
VQRIFENGYD | PVNLLNDIVI | LQLNGSATIN | ANVQVAQLPA | QGRRLGNGVQ |
200:
CLAMGWGLLG | RNRGIASVLQ | ELNVTVVTSL | CRRSNVCTLV | RGRQAGVCFG |
250:
DSGSPLVCNG | LIHGIASFVR | GGCASGLYPD | AFAPVAQFVN | WIDSIIQRSE |
267:
DNPCPHPRDP | DPASRTH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Neutrophil elastase
ELISA Kit for Human Neutrophil elastase
ELISA Kit for Human Neutrophil elastase
CLIA Kit for Human Neutrophil elastase
CLIA Kit for Human Neutrophil elastase
CLIA Kit for Human Neutrophil elastase
Polyclonal Antibody for Human Neutrophil elastase
Polyclonal Antibody for Human Neutrophil elastase
Polyclonal Antibody for Human Neutrophil elastase
Monoclonal Antibody for Human Neutrophil elastase
Monoclonal Antibody for Human Neutrophil elastase
Monoclonal Antibody for Human Neutrophil elastase
Protein for Human Neutrophil elastase
Protein for Human Neutrophil elastase
Protein for Human Neutrophil elastase
R&D Technical Data
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-219; LEU-257 AND LEU-262
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 30-267
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 30-247
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PRELIMINARY PROTEIN SEQUENCE OF 30-103
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 30-49
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 30-49
tissue :
Neutrophil .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 75-267
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 123-267
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 262-267
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NOTCH2NL;CHARACTERIZATION OF VARIANT CH GLN-220
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-88 AND ASN-173
tissue :
Liver .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS)
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS)
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CH VAL-61; PHE-206 AND GLN-220
23.
"Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia."
Dale D.C.
,
Person R.E.
,
Bolyard A.A.
,
Aprikyan A.G.
,
Bos C.
,
Bonilla M.A.
,
Boxer L.A.
,
Kannourakis G.
,
Zeidler C.
,
Welte K.
,
Benson K.F.
,
Horwitz M.
Blood96:2317-2322(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 THR-57; THR-60; SER-71; MET-101; LEU-126; LEU-139; VAL-210 AND ARG-214;VARIANT CH LEU-139
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 TYR-55; GLU-85; PRO-GLN-LEU-123 INS; LEU-126; SER-151; 190-VAL--PHE-199 DEL AND ARG-205
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SCN1 ARG-71
26.
"Mutations in the ELA2 gene correlate with more severe expression of neutropenia: a study of 81 patients from the French Neutropenia Register."
Bellanne-Chantelot C.
,
Clauin S.
,
Leblanc T.
,
Cassinat B.
,
Rodrigues-Lima F.
,
Beaufils S.
,
Vaury C.
,
Barkaoui M.
,
Fenneteau O.
,
Maier-Redelsperger M.
,
Chomienne C.
,
Donadieu J.
Blood103:4119-4125(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 LEU-42; PRO-47; LEU-53; PRO-81; PRO-84; PRO-121; PRO-127; LEU-139; PRO-152 AND 190-VAL--199-PHE DEL;VARIANTS CH LEU-43; PHE-46; MET-82; LEU-126; LEU-139; 190-VAL--199-PHE DEL; ILE-219 AND GLN-220;VARIANT LEU-262
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 LEU-98 AND LEU-101;CHARACTERIZATION OF VARIANTS SCN1 LEU-98 AND LEU-101
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SCN1 VAL-57
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 ARG-44; CYS-46; TYR-53; ARG-85; ARG-203 AND CYS-203
30.
"Ela2 mutations and clinical manifestations in familial congenital neutropenia."
Shiohara M.
,
Shigemura T.
,
Saito S.
,
Tanaka M.
,
Yanagisawa R.
,
Sakashita K.
,
Asada H.
,
Ishii E.
,
Koike K.
,
Chin M.
,
Kobayashi M.
,
Koike K.
J. Pediatr. Hematol. Oncol.31:319-324(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 LEU-42; PRO-81; MET-101 AND LEU-126
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 VAL-25 AND THR-166
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 PRO-59 AND GLU-235
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SCN1 SER-57
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 THR-131; PRO-152; GLY-235 AND 190-VAL--199-PHE DEL
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SCN1 VAL-25; LEU-42; LEU-43; GLU-45; PHE-46; ARG-47; PRO-49; SER-55; ARG-56; SER-57; THR-57; VAL-57; PRO-59; 60-ILE-ALA-61 DELINS ARG; THR-60; VAL-61; VAL-65 DEL; 66-MET--HIS-70 DEL; TRP-67; ARG-71; PHE-71; TYR-71; GLY-72; GLY-80; PRO-81; MET-82; PRO-84; GLU-85; LEU-98; MET-98; LEU-101; MET-101; LEU-103; PRO-103; ASN-120; PHE-120; SER-120; PRO-121; HIS-123; ILE-124; LEU-126; ASP-127; THR-131; ASP-136; ARG-139; LEU-139; PHE-151; TRP-151; TYR-151; PRO-152; ASP-153; PRO-153; ARG-156; CYS-156; THR-166; ARG-203; ARG-205; SER-206; GLY-208; ARG-214; GLU-214; ILE-219; GLN-220; PRO-233; GLU-235 AND GLY-235;VARIANTS CH LEU-45; VAL-61; PRO-81; LEU-97; ASN-104; PHE-120; LEU-126; LEU-139; HIS-143; 190-VAL--199-PHE DEL; CYS-203; ILE-209; TRP-210; ILE-219 AND GLN-220;VARIANTS VAL-118; ARG-125; MET-135 AND LEU-257